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[Characterisation of Candida sp. isolated from patients after abdominal surgery]

V Adámková, A Vaňková, J Ulrych

    Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti
    |January 9, 2018
    PubMed
    Abstract

    Insights

    Intraabdominal candidiasis (IAC) is common after GI surgery. This study found Candida strains were susceptible to echinocandins, offering insights into invasive candidiasis treatment.

    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Surgical Infections

    Background:

    • Intraabdominal candidiasis (IAC) is a significant complication following gastrointestinal (GI) surgery or perforation.
    • Epidemiological studies often overlook IAC, focusing primarily on candidemia.
    • Blood cultures have limited utility in diagnosing abdominal candidiasis.

    Purpose of the Study:

    • To analyze Candida species isolated from the abdominal cavity in patients post-surgery.
    • To determine the mortality rate associated with IAC.
    • To assess the antifungal susceptibility patterns of isolated Candida strains.

    Main Methods:

    • Retrospective analysis of Candida isolates from clinical specimens.
    • Study included patients who underwent abdominal surgery between January 1 and October 31, 2016.
    • Identification of Candida species and antifungal susceptibility testing.

    Main Results:

    • 33 patients with intraabdominal Candida isolates were analyzed.
    • The overall mortality rate was 15.2%.
    • Candida albicans and Candida glabrata were the most frequent species; all isolates were susceptible to echinocandins.

    Conclusions:

    • The clinical significance of Candida isolation from the abdominal space requires further clarification.
    • Echinocandins demonstrate in vitro efficacy against common Candida species found in IAC.
    • Improved laboratory diagnostics are crucial for interpreting Candida findings in abdominal infections.

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