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Razor-printed sticker microdevices for cell-based applications.

Loren E Stallcop1, Yasmín R Álvarez-García, Ana M Reyes-Ramos

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|January 11, 2018
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Summary
This summary is machine-generated.

This study characterizes a biocompatible adhesive tape for ultra-rapid prototyping of microscale devices. The tape enables affordable, rapid cell-based assay development and integration of diverse materials for advanced functionalities.

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Area of Science:

  • Microscale device fabrication
  • Cell-based assay development
  • Biocompatible materials

Background:

  • Tape-based razor-printing offers rapid, affordable microscale device prototyping.
  • Integration into cell-based assays is limited by lack of characterized biocompatible tapes.
  • This hinders exploration of advanced applications.

Purpose of the Study:

  • Characterize ARCare 90106, a double-sided adhesive tape, for microscale device fabrication.
  • Validate its performance in cell-based assay development.
  • Demonstrate novel applications enabled by the tape's properties.

Main Methods:

  • Fabricated microscale devices using ARCare 90106 tape.
  • Assessed cell viability, small molecule sequestration, leaching, fluorescence microscopy, and outgassing.
  • Compared tape-based devices to 96-well plates and PDMS microdevices.
  • Demonstrated material integration capabilities.

Main Results:

  • ARCare 90106 tape demonstrated biocompatibility and suitable performance for cell-based assays.
  • The ultra-rapid (<1 hr/prototype) and affordable (<$0.05/prototype) method showed promise.
  • Successful integration of disparate materials (polystyrene to glass, membranes, biomaterials) was achieved.
  • The approach was readily adopted by new users.

Conclusions:

  • ARCare 90106 is a promising biocompatible adhesive for tape-based razor-printing in microscale assay development.
  • This work overcomes a critical barrier, enabling wider integration and adoption.
  • The study highlights potential for new applications in advanced sticker-device functionalities.