Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.1K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.1K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.4K
Overview
80.4K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

211
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
211
Liver Histology01:27

Liver Histology

4.5K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
4.5K
Liver Physiology01:30

Liver Physiology

3.9K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.9K
Liver Regeneration01:24

Liver Regeneration

4.5K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hematuria as a risk factor for progression of chronic kidney disease and death: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.

BMC nephrology·2018
Same author

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

PloS one·2018
Same author

[Classification, distribution and change of Uighur medicinal materials resources].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2018
Same author

[Determination of 3 components in Xinjiang Ziziphora bungeana by HPLC].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2018
Same author

Self-Reported Tobacco, Alcohol, and Illicit Drug Use and Progression of Chronic Kidney Disease.

Clinical journal of the American Society of Nephrology : CJASN·2018
Same author

Trends in Prevalence and Control of Hypertension According to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline.

Journal of the American Heart Association·2018
Same journal

Elevated TREM2 Expression in Tumor-associated Macrophages Suppresses Cytotoxic T Cell Infiltration and Facilitates Immune Escape in Colorectal Cancer.

Cellular and molecular gastroenterology and hepatology·2026
Same journal

Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids.

Cellular and molecular gastroenterology and hepatology·2026
Same journal

Conducting the Orchestra: Non-Parenchymal Cells Direct Hepatocyte Functions in Steatotic Liver Disease.

Cellular and molecular gastroenterology and hepatology·2026
Same journal

IGF2BP1-Mediated m6A Modification Stabilizes HMGA2 mRNA to Promote Intrahepatic Cholangiocarcinoma Progression.

Cellular and molecular gastroenterology and hepatology·2026
Same journal

Bacteroides acidifaciens attenuates Concanavalin A-induced liver injury by remodeling bile acids to suppress CD95-mediated hepatocyte apoptosis via the TGR5-FOSL1 pathway.

Cellular and molecular gastroenterology and hepatology·2026
Same journal

Red Meat, Plant Protein, and Colitis: Emerging Roles for the Gut Microbiome and Bile Acids.

Cellular and molecular gastroenterology and hepatology·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

930

Engineered Livers for Infectious Diseases.

Nil Gural1,2, Liliana Mancio-Silva2,3, Jiang He2,3

  • 1Harvard-MIT Department of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Boston, Massachusetts.

Cellular and Molecular Gastroenterology and Hepatology
|January 12, 2018
PubMed
Summary
This summary is machine-generated.

Engineered liver systems aid in discovering new treatments for liver-infectious diseases like hepatitis B, C, and malaria. Choosing the right model is key for advancing biologic discovery and therapeutic development.

Keywords:
2D, 2-dimensional3D3D, 3-dimensionalEBOV, Ebola virusFalciparumHBC, hepatitis C virusHBVHBV, hepatitis B virusHCVHLC, hepatocyte-like cellsHepatotropicLASV, Lassa virusLiverLiver ModelsMPCC, micropatterned coculture systemMalariaPCR, polymerase chain reactionPathogenSACC, self-assembling cocultureVivaxiHLC, induced pluripotent stem cell–derived hepatocyte-like cellsin vitroin vivo

More Related Videos

Biocontained Carcass Composting for Control of Infectious Disease Outbreak in Livestock
14:34

Biocontained Carcass Composting for Control of Infectious Disease Outbreak in Livestock

Published on: May 6, 2010

11.4K
Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

4.0K

Related Experiment Videos

Last Updated: Feb 15, 2026

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

930
Biocontained Carcass Composting for Control of Infectious Disease Outbreak in Livestock
14:34

Biocontained Carcass Composting for Control of Infectious Disease Outbreak in Livestock

Published on: May 6, 2010

11.4K
Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

4.0K

Area of Science:

  • Biotechnology
  • Infectious Diseases
  • Hepatology

Background:

  • Engineered liver systems, including 2D cocultures and 3D organoids, are crucial for studying liver-dependent infectious diseases.
  • The species-specificity of human hepatotropic pathogens necessitates advanced research models.

Purpose of the Study:

  • To review advances in engineered liver systems for studying viral hepatitis (B and C) and malaria.
  • To emphasize the importance of selecting appropriate model systems and readouts for specific research questions.

Main Methods:

  • Utilizing various engineered liver platforms such as 2D cocultures, 3D organoids, and humanized mice.
  • Analyzing progress in the study of hepatitis B virus (HBV), hepatitis C virus (HCV), Plasmodium falciparum, and Plasmodium vivax.

Main Results:

  • Significant progress has been made in biologic discovery and therapeutic agent development using current engineered liver models.
  • These systems have proven essential for understanding liver-dependent infectious diseases.

Conclusions:

  • Engineered liver systems are vital tools for advancing research in liver-infectious diseases.
  • While improvements like incorporating immune components are needed, current platforms facilitate substantial progress.
  • The strategic selection of model systems and readouts is critical for experimental success, even without full human physiology recapitulation.