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Moderately hypofractionated prostate external-beam radiotherapy: an emerging standard
Jarad M Martin1, Stephane Supiot2, Paul J Keall3
11 School of Medicine and Public Health, University of Newcastle , Callaghan, New South Wales, NSW , Australia.
The British Journal of Radiology
|January 12, 2018
Summary
Curative external-beam radiotherapy is now safely and effectively delivered using fewer treatments. This review covers the supporting data, implementation strategies, and future research in radiation oncology.
Area of Science:
- Radiation Oncology
- Medical Physics
Background:
- Conventional radiotherapy schedules are being re-evaluated for efficiency.
- Advances in technology allow for dose escalation and hypofractionation.
Purpose of the Study:
- To review evidence supporting reduced treatment courses in external-beam radiotherapy.
- To discuss practical implementation of shorter radiotherapy regimens.
- To explore future directions in radiation therapy optimization.
Main Methods:
- Systematic review of clinical trials and practice-based evidence.
- Analysis of dosimetric and clinical outcomes data.
- Evaluation of implementation strategies in diverse clinical settings.
Main Results:
- Evidence supports safe and effective curative external-beam radiotherapy with approximately 50% fewer treatments.
- Hypofractionated regimens demonstrate comparable or improved outcomes in select cases.
- Implementation requires careful patient selection and quality assurance.
Conclusions:
- Reduced treatment courses represent a safe and effective paradigm shift in external-beam radiotherapy.
- Hypofractionation enhances patient convenience and potentially reduces healthcare costs.
- Further research should focus on refining patient selection and long-term outcomes.
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