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Updated: Feb 15, 2026

Using Graphene Liquid Cell Transmission Electron Microscopy to Study in Situ Nanocrystal Etching
Published on: May 17, 2018
Nanometer Resolution Elemental Mapping in Graphene-Based TEM Liquid Cells
Daniel J Kelly1, Mingwei Zhou1, Nick Clark1
1School of Materials, ‡School of Physics and Astronomy, and §National Graphene Institute, University of Manchester , Oxford Road, Manchester, M13 9PL, United Kingdom.
Abstract:
We demonstrate a new design of graphene liquid cell consisting of a thin lithographically patterned hexagonal boron nitride crystal encapsulated on both sides with graphene windows. The ultrathin window liquid cells produced have precisely controlled volumes and thicknesses and are robust to repeated vacuum cycling. This technology enables exciting new opportunities for liquid cell studies, providing a reliable platform for high resolution transmission electron microscope imaging and spectral mapping. The presence of water was confirmed using electron energy loss spectroscopy (EELS) via the detection of the oxygen K-edge and measuring the thickness of full and empty cells. We demonstrate the imaging capabilities of these liquid cells by tracking the dynamic motion and interactions of small metal nanoparticles with diameters of 0.5-5 nm. We further present an order of magnitude improvement in the analytical capabilities compared to previous liquid cell data with 1 nm spatial resolution elemental mapping achievable for liquid encapsulated bimetallic nanoparticles using energy dispersive X-ray spectroscopy (EDXS).
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