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LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles
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Osteosarcoma-derived extracellular vesicles induce a tumor-like phenotype in normal recipient cells

Enrica Urciuoli1,2, Ezio Giorda3, Marco Scarsella3

  • 1Multifactorial Diseases Unit-Research Laboratories, Bambino Gesù Children's Hospital, Rome, Italy.

Journal of Cellular Physiology
|January 12, 2018
PubMed
Summary

Osteosarcoma cells release extracellular vesicles (EVs) that transform normal cells into tumor-like cells. These EVs promote cancer cell growth and spread by altering recipient cell behavior and gene expression.

Keywords:
bone tumorsextracellular vesiclesoncogenic transformationosteosarcoma

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