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Nanoparticles-Emerging Potential for Managing Leukemia and Lymphoma.
Raquel Vinhas1, Rita Mendes1, Alexandra R Fernandes1
1UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Caparica, Portugal.
Frontiers in Bioengineering and Biotechnology
|January 13, 2018
Summary
Nanoparticles (NPs) offer advanced cancer diagnosis and treatment, especially for liquid tumors where the EPR effect is absent. This review details nanoconstructs for managing liquid cancers and their role in theranostics.
Area of Science:
- Biomedical Engineering
- Oncology
- Materials Science
Background:
- Nanotechnology, particularly nanoparticles (NPs), enhances cancer diagnosis and treatment sensitivity and selectivity.
- Nanomedicine traditionally leverages the enhanced permeability and retention (EPR) effect for solid tumors.
- Liquid tumors present unique challenges as the EPR effect is not a significant factor.
Purpose of the Study:
- To review the current state of nanoconstructs for managing liquid tumors.
- To explore innovative diagnostic and therapeutic approaches for leukemia and lymphoma using NPs.
- To discuss the role of NPs in theranostics for liquid cancers.
Main Methods:
- Review of preclinical studies and clinical trials on nanomedicines for liquid tumors.
- Analysis of nanoparticle properties for enhanced drug delivery and overcoming resistance.
- Evaluation of nanoplatforms for theranostic applications in liquid cancers.
Main Results:
- NPs provide novel, non-invasive methods for diagnosing and treating liquid tumors.
- Nanomedicines demonstrate improved therapeutic efficacy and drug delivery compared to conventional chemotherapy.
- Nanoparticles are crucial for developing theranostic strategies in liquid cancer management.
Conclusions:
- Nanotechnology offers significant promise for advancing the care of patients with liquid tumors.
- NPs are versatile tools for both early detection and effective treatment of liquid cancers.
- The integration of NPs into theranostic platforms represents a key future direction for liquid tumor management.
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