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[Expression of vascular intercellular adhesion molecule-1 and its significance in children with bronchiolitis]

Xiao-Ming Zhang1, Hai-Tao Zhu, Ming Chang

  • 1Department of Pediatrics, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, China. zhangxmzj@126.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|January 17, 2018
PubMed

Insights

Intercellular adhesion molecule-1 (ICAM-1) levels are elevated in children with bronchiolitis, correlating with disease severity. ICAM-1 levels decrease during recovery, indicating its role in the condition.

Area of Science:

  • Pediatric Pulmonology
  • Immunology
  • Biomarkers

Background:

  • Bronchiolitis is a common respiratory infection in infants and young children.
  • Intercellular adhesion molecule-1 (ICAM-1) is implicated in inflammatory processes.

Purpose of the Study:

  • To evaluate serum and sputum ICAM-1 levels in pediatric bronchiolitis.
  • To determine the association between ICAM-1 and bronchiolitis severity and pathogenesis.

Main Methods:

  • Enrolled 67 children with bronchiolitis (mild, moderate, severe) and 20 healthy controls.
  • Measured ICAM-1 levels in serum and induced sputum supernatant using ELISA.
  • Compared ICAM-1 levels across disease severity and stages (acute vs. recovery).

Main Results:

  • Significantly higher ICAM-1 levels in serum and sputum of bronchiolitis patients compared to controls (P<0.01).
  • Progressively increased ICAM-1 levels with increasing disease severity (mild < moderate < severe) (P<0.01).
  • Significantly reduced ICAM-1 levels in the recovery stage compared to the acute stage (P<0.01).
  • Positive correlation between serum and sputum ICAM-1 levels in the acute stage (r=0.875, P<0.001).

Conclusions:

  • ICAM-1 is a relevant biomarker in pediatric bronchiolitis.
  • Elevated ICAM-1 expression is associated with increased disease severity.
  • ICAM-1 plays a role in the pathogenesis of bronchiolitis.
Abstract

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