Related Experiment Video
Updated: Feb 15, 2026
09:38
Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans
Published on: November 29, 2013
17.6K
[Fumarates - far more than a dietary supplement].
Wolf-Henning Boehncke1, Nicolo Costantino Brembilla2
1Service de dermatologie et vénéréologie, Département des spécialités en médecine, HUG, 1211 Genève 14.
Revue Medicale Suisse
|January 17, 2018
Summary
Fumaric acid esters, initially used for psoriasis, are now recognized for their anti-inflammatory properties. Dimethylfumaric acid ester is now a globally available treatment for psoriasis and multiple sclerosis.
Area of Science:
- Biochemistry
- Dermatology
- Neurology
Background:
- Fumaric acid is integral to the citric acid cycle.
- Early observations linked psoriasis to metabolic disturbances.
- The anti-inflammatory mechanisms of fumaric acid esters are increasingly understood.
Purpose of the Study:
- To review the therapeutic applications of fumaric acid esters.
- To highlight the anti-inflammatory mechanisms and clinical use of dimethylfumaric acid ester.
- To inform general practitioners about this emerging treatment.
Main Methods:
- Literature review of fumaric acid ester applications.
- Analysis of the anti-inflammatory pathways.
- Summary of clinical data for psoriasis and multiple sclerosis treatment.
Main Results:
- Fumaric acid esters demonstrate significant anti-inflammatory effects.
- Dimethylfumaric acid ester is approved for multiple sclerosis and psoriasis.
- The drug is becoming a popular therapeutic option.
Conclusions:
- Fumaric acid esters represent a significant therapeutic advance.
- General practitioners should be aware of the benefits and risks of dimethylfumaric acid ester.
- Further understanding of adverse effects is crucial for patient safety.
Related Concept Videos
01:23Dietary Connections
62.3K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
62.3K
01:28Proteins: Dietary Sources and Requirements
1.8K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.8K
01:15Carbohydrates: Dietary Sources and Requirements
1.9K
Carbohydrates are predominantly obtained from plant sources. With the exception of lactose found in milk and insignificant glycogen amounts in meat, most consumed carbohydrates have plant origins. Monosaccharides and disaccharides, or sugars, can be sourced from fruits, honey, milk, sugar cane, and sugar beets. Grains and vegetables are rich in the polysaccharide starch. Two types of polysaccharides provide fiber: cellulose, which is abundant in many vegetables, forms undigestible roughage or...
1.9K
01:18Lipids: Dietary Sources and Requirements
2.2K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.2K
02:36The Citric Acid Cycle
163.0K
The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules.
163.0K
01:06Lipid Digestion
100.0K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
100.0K