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Mitomycin C 0.02 and 0.002% efficacy in preventing haze after photorefractive keratectomy

L M Coelho1, R O Sieiro2

  • 1Instituto de Olhos de Belo Horizonte (IOBH), Universidade Federal de Minas Gerais (UFMG), Padre Rolim Street, 541, Belo Horizonte, MG, Brazil. leticiamariacoelho@gmail.com.

International Ophthalmology
|January 18, 2018
PubMed
Abstract

Insights

Low-concentration mitomycin C (MMC) 0.002% effectively prevents haze after photorefractive keratectomy (PRK). This study suggests using lower MMC concentrations to minimize potential long-term complications.

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Pharmacology

Background:

  • Post-photorefractive keratectomy (PRK) haze is a common complication.
  • Mitomycin C (MMC) is used to inhibit fibroblast proliferation and prevent haze.
  • Optimal MMC concentration for haze prevention requires further investigation.

Purpose of the Study:

  • To compare the efficacy of mitomycin C (MMC) 0.002% versus 0.02% in preventing corneal haze after photorefractive keratectomy (PRK).

Main Methods:

  • A prospective study involving 130 patients undergoing PRK for myopia or myopic astigmatism.
  • MMC 0.02% applied to the right eye (group 1) and 0.002% to the left eye (group 2) for 30 seconds post-PRK.
  • Haze intensity was quantified at 1, 3, 6, and 12 months postoperatively.

Main Results:

  • No statistically significant difference in haze incidence or intensity was observed between the 0.02% and 0.002% MMC groups at any time point.
  • Haze incidence was 7.7% in the 0.02% group and 5.4% in the 0.002% group at 12 months.
  • No correlation was found between haze and patient age, gender, or spherical equivalent.

Conclusions:

  • Mitomycin C (MMC) at a 0.002% concentration is effective in preventing haze after photorefractive keratectomy (PRK).
  • Given the unproven long-term safety of higher MMC concentrations, lower concentrations are recommended to mitigate potential complications.
  • Further research into the long-term safety profile of MMC in corneal surgery is warranted.
Keywords:
Corneal hazeMitomycin CPRK complicationsPhotorefractive keratectomyRefractive surgical procedures

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