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09:29
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
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Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative
Jessica L Christenson1, Jane B Trepel2, Haythem Y Ali3
1Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Hormones & Cancer
|January 18, 2018
Summary
Androgen receptor (AR) targeted therapies show promise for a subset of triple-negative breast cancers (TNBCs). Further research is defining AR
Area of Science:
- Oncology
- Endocrinology
- Cancer Biology
Background:
- Triple-negative breast cancer (TNBC) lacks targeted therapies, with chemotherapy as the primary treatment.
- The androgen receptor (AR) is expressed in a subset of TNBCs, suggesting it as a potential therapeutic target.
- The precise role and dependency of TNBC on AR, especially after treatment, require further elucidation.
Purpose of the Study:
- To review preclinical and clinical data on AR-positive (AR+) TNBC.
- To explore the influence of AR on cancer stemness and immune regulation in TNBC.
- To discuss challenges in AR detection and novel therapeutic strategies targeting AR and androgen production.
Main Methods:
- Review of existing preclinical and clinical studies on AR+ TNBC.
- Discussion of emerging methods for assessing AR status.
- Analysis of AR's role in stemness, immune response, and therapeutic resistance.
Main Results:
- AR plays a multifaceted role in AR+ TNBC, influencing stemness and immune evasion.
- Monitoring AR protein levels presents challenges, necessitating improved detection methods.
- Combined inhibition of androgen production and AR signaling is a potential therapeutic avenue.
Conclusions:
- Targeting AR and androgen production offers a promising alternative or addition to chemotherapy for select TNBC patients.
- Further characterization of AR's mechanisms in TNBC is crucial for optimizing treatment strategies.
- New therapies targeting AR may expand treatment options for patients with limited alternatives.
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