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Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis
1Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an, 710069, People's Republic of China.
Natural Products and Bioprospecting
|January 18, 2018
Summary
The endocannabinoid system influences many bodily functions. This review explores cannabinomimetic lipids from marine sources, detailing their extraction and synthesis for potential therapeutic applications.
Area of Science:
- Neuroscience
- Marine Biology
- Biochemistry
Background:
- The endocannabinoid system regulates critical physiological and cognitive functions, including fertility, mood, appetite, and memory.
- Discovery of cannabinoid receptors CB1 and CB2 marked a significant advancement in understanding this system.
- Anandamide, the first identified endogenous cannabinoid, modulates neurotransmitter release via CB1/CB2 receptors.
Purpose of the Study:
- To review cannabinomimetic lipids discovered in marine organisms.
- To provide an overview of extraction and synthesis methods for these compounds.
Main Methods:
- Literature review of studies on marine-derived cannabinomimetic lipids.
- Analysis of reported extraction and chemical synthesis techniques.
Main Results:
- Marine organisms yield lipids structurally similar to anandamide.
- These compounds exhibit potential as cannabinoid receptor modulators.
Conclusions:
- Cannabinomimetic lipids from marine sources represent a promising area for research.
- Further investigation into their extraction and synthesis is warranted for potential therapeutic development.
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