Related Experiment Video
Updated: Feb 15, 2026

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay
Published on: February 7, 2025
Using Blood Donor-Derived ABO and RhD Blood Groups Helps to Detect Wrong Blood in Tube Errors in Recipients
Christoffer Dellgren1, Mark H Yazer2, Ulrik Sprogøe1
1Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
Background:
Comparing the ABO and RhD group of a recipient's current pre-transfusion sample against their historical group is an important means of detecting wrong blood in tube (WBIT) errors. This study investigated the utility of using the donor ABO and RhD group as the historical check for recipients.
Methods:
A single database stores serological information on blood donors, pregnant women, and patients throughout southern Denmark. A donor ABO and RhD group can be the historical blood group should that donor later require a transfusion. This database was searched to determine how often the ABO and RhD group on a recipient's current pre-transfusion sample was discrepant with their historical donor-derived blood group.
Results:
During about 21 years, ABO and RhD groupings were performed on 76,455 blood donors and on 424,697 patients. There were 13,630/424,697 (3.2%) patients who had their donor-derived ABO and RhD group used as the historical comparison with the current sample; 6/13,630 (0.04%) of the current pre-transfusion samples on these patients were discrepant with the donor-derived historical group because of WBIT errors. Seven other discrepancies with the donor-derived blood group were also found.
Conclusion:
Accessing the donor-derived ABO and RhD group can be an important safeguard against WBIT-mediated mistransfusions.
Related Concept Videos
The ABO Blood Group
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Errors occurring during blood pressure monitoring
Several factors...
Composition of Blood
Formed elements constitute the remaining 45% of the blood volume. These...
Blood Flow
Blood Types
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Blood Pressure

