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A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
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Histopathological findings in pregnancy associated cutaneous hyperpigmentation
Angel Fernandez-Flores1,2,3, Juan M Barja4, Alejandro Vilas-Sueiro4
1Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.
Journal of Cutaneous Pathology
|January 19, 2018
Summary
Extensive skin hyperpigmentation during pregnancy, even in non-sun-exposed areas, is rare. This case study details a 30-year-old woman with widespread skin darkening, which significantly improved postpartum.
Area of Science:
- Dermatology and Obstetrics
Background:
- Hyperpigmentation affects up to 90% of pregnant women, typically in sun-exposed areas.
- Extensive, non-sun-exposed hyperpigmentation during pregnancy is uncommon.
Observation:
- A 30-year-old woman (phototype V) presented with extensive skin hyperpigmentation in the 37th week of pregnancy.
- Affected areas included axillae, abdomen (linea nigra, umbilicus), lower back, buttocks, and intertriginous zones.
Findings:
- Histopathology revealed a hyperpigmented basal epidermis with increased melanocytes and hyperpigmented keratinocytes.
- No melanocytic atypia, nests, or iron deposits were observed.
- Estrogen and progesterone receptor stains were negative.
Implications:
- This case highlights an unusual presentation of pregnancy-related hyperpigmentation.
- The condition showed significant improvement three months after delivery, suggesting a transient, pregnancy-induced process.
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