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Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
Published on: June 15, 2018
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Offline stimulation of human parietal cortex differently affects resting EEG microstates
Pierpaolo Croce1,2, Filippo Zappasodi3,4, Paolo Capotosto1,2
1Department of Neuroscience Imaging and Clinical Science, "G. d'Annunzio" University, Chieti, Italy.
Scientific Reports
|January 21, 2018
Summary
Transcranial magnetic stimulation (TMS) can alter brain activity. Inhibiting parietal networks, specifically key nodes of the dorsal attention (DAN) and default mode networks (DMN), caused significant changes in electroencephalography (EEG) microstate C.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Brain Imaging
Background:
- Transcranial magnetic stimulation (TMS) effects on electroencephalography (EEG) measures are documented.
- The potential for focal TMS to induce global brain state reorganization remains under investigation.
Purpose of the Study:
- To investigate if offline inhibitory TMS targeting parietal regions can globally alter functional brain states, assessed via EEG microstates.
- To determine the causal relationship between specific network interference and microstate modifications.
Main Methods:
- 16 healthy subjects underwent TMS targeting five parietal areas and a sham stimulation.
- EEG microstates were recorded before and after each stimulation condition.
- Analysis focused on changes in the topography of canonical EEG microstates (A, B, C, D).
Main Results:
- Sham stimulation and ventral site stimulation did not alter EEG microstates.
- Interference with parietal key nodes of the dorsal attention network (DAN) and default mode network (DMN) specifically altered microstate C topography.
- Microstates A, B, and D remained unaffected by the parietal interference.
Conclusions:
- This study provides the first causal evidence that magnetic interference can modify EEG microstates.
- The observed changes in microstate C, linked to the cingulo-opercular network (CON), suggest a regional specificity of TMS effects.
- Findings support a functional link between the CON, DAN, and DMN at rest.
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