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Topical drug delivery devices: A review
Christian J F Bertens1, Marlies Gijs1, Frank J H M van den Biggelaar2
1Department of Ophthalmology, University Eye Clinic Maastricht, University Medical Center +, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands; Department of Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands; Chemelot Institute for Science and Technology (InSciTe), Urmonderbaan 20F, 6167 RD Geleen, The Netherlands.
Experimental Eye Research
|January 22, 2018
Summary
Conventional eye drops have low effectiveness for ocular diseases. New medical devices offer improved drug delivery, enhancing patient compliance and therapeutic outcomes for eye conditions.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Pharmaceutics
Background:
- Conventional ocular drug delivery methods like eye drops and ointments face challenges with patient compliance and achieving effective drug concentrations at the target site.
- These limitations necessitate the development of advanced medical devices for improved ocular drug delivery.
Purpose of the Study:
- To review existing and emerging drug delivery devices for ocular diseases.
- To highlight the need for enhanced topical drug delivery strategies to improve therapeutic efficacy.
Main Methods:
- Review of various ocular drug delivery devices, including resorbable, oval/ring-shaped, rod-shaped, punctum plugs, contact lenses, and corneal shields.
- Analysis of marketed products and devices currently in clinical trials.
Main Results:
- Several ocular drug delivery devices have been developed, with a few reaching the market (e.g., Mydriasert®, Ozurdex®).
- Many other devices are undergoing clinical investigation, indicating active research in this field.
Conclusions:
- There is a significant need for enhanced topical drug delivery systems for ocular diseases.
- Collaboration between academia, industry, and regulatory authorities, alongside parallel strategies in device and formulation development and pharmacokinetic understanding, is crucial for improving treatment outcomes.
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