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Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies
Alexander G Tskhovrebov1,2, Anna A Vasileva1, Richard Goddard2
1St. Petersburg State University , Universitetskaya Nab. 7/9, St. Petersburg, Russian Federation.
Abstract:
Well-defined diazotates are scarce. Here we report the synthesis of unprecedented homoleptic palladium(II) diazotate complexes. The palladium(II)-mediated nitrosylation of 2-aminopyridines with NaNO2 results in the formation of metal-stabilized diazotates, which were found to be cytotoxic to human ovarian cancer cells.
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