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Ivar Tjernberg1, Inger Gustafsson2
1Linkopings Universitet Institutionen for klinisk och experimentell medicin - Klinisk kemi och transfusionsmedicin, Landstinget i Kalmar län Kalmar, Sweden Clinical and Experimental Medicine, Linköping University, Sweden - Clinical chemistry and transfusion medicine, Kalmar County Council, Sweden Kalmar, Sweden.
Summary
Monoclonal gammopathy can cause falsely high plasma creatinine levels due to analytical interference. This interference is often undetected, highlighting the need for laboratory consultation with unexpected results.
Area of Science:
- Clinical Biochemistry
- Laboratory Medicine
Background:
- Analytical interference can lead to inaccurate clinical biochemical results.
- Common interferences like hemolysis, icterus, and lipemia are usually detected.
- Less common interferences, such as those from heterophilic antibodies, can be challenging to identify.