Related Experiment Video
Updated: Feb 15, 2026
13:05
De Novo Generation of Somatic Stem Cells by YAP/TAZ
Published on: May 7, 2018
9.7K
DNA binding partners of YAP/TAZ
Min-Kyu Kim1, Ju-Won Jang1, Suk-Chul Bae1
1Department of Biochemistry, College of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju 28644, Korea.
BMB Reports
|January 26, 2018
Summary
The Hippo pathway regulates organ size and cancer by controlling YAP/TAZ proteins. YAP
Area of Science:
- Cell Biology
- Molecular Biology
- Cancer Research
Background:
- The Hippo signaling pathway is crucial for maintaining tissue homeostasis and organ size.
- It regulates the activity of transcriptional coactivators YES-associated protein (YAP) and PDZ-binding protein TAZ.
- Hippo signaling interacts with other pathways like WNT, BMPs, Notch, GPCRs, and Hedgehog.
Purpose of the Study:
- To summarize the roles of YAP based on its DNA-binding partners.
- To discuss the context-dependent functions of YAP and TAZ.
- To explore YAP's dual role as an oncogene or tumor suppressor.
Main Methods:
- Review of existing literature on Hippo signaling and YAP/TAZ.
- Analysis of YAP's interactions with various DNA-binding proteins.
- Discussion of experimental evidence supporting YAP's context-dependent functions.
Main Results:
- YAP and TAZ require DNA-binding partners to regulate gene expression.
- TEAD family members are key YAP/TAZ partners, often promoting proliferation (oncogenic role).
- YAP can also bind tumor suppressors like RUNXs and p73, suggesting a tumor-suppressive role.
Conclusions:
- YAP's function as an oncogene or tumor suppressor is determined by its binding partners.
- The context-dependent activity of YAP/TAZ is critical for understanding their roles in health and disease.
- Further research into YAP's interactions can reveal new therapeutic strategies for cancer.
Related Concept Videos
01:03Single-Strand DNA Binding Proteins
16.8K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
16.8K
02:05DNA as a Genetic Template
28.0K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
28.0K
02:18The Equilibrium Binding Constant and Binding Strength
15.3K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
15.3K
00:49Ligand Binding and Linkage
5.7K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked. In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.7K
02:13Cooperative Binding of Transcription Regulators
7.4K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome. Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.4K
00:55DNA Helicases
24.2K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.2K