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DNA binding partners of YAP/TAZ

Min-Kyu Kim1, Ju-Won Jang1, Suk-Chul Bae1

  • 1Department of Biochemistry, College of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju 28644, Korea.

BMB Reports
|January 26, 2018
PubMed

Insights

The Hippo pathway regulates organ size and cancer by controlling YAP/TAZ proteins. YAP

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The Hippo signaling pathway is crucial for maintaining tissue homeostasis and organ size.
  • It regulates the activity of transcriptional coactivators YES-associated protein (YAP) and PDZ-binding protein TAZ.
  • Hippo signaling interacts with other pathways like WNT, BMPs, Notch, GPCRs, and Hedgehog.

Purpose of the Study:

  • To summarize the roles of YAP based on its DNA-binding partners.
  • To discuss the context-dependent functions of YAP and TAZ.
  • To explore YAP's dual role as an oncogene or tumor suppressor.

Main Methods:

  • Review of existing literature on Hippo signaling and YAP/TAZ.
  • Analysis of YAP's interactions with various DNA-binding proteins.
  • Discussion of experimental evidence supporting YAP's context-dependent functions.

Main Results:

  • YAP and TAZ require DNA-binding partners to regulate gene expression.
  • TEAD family members are key YAP/TAZ partners, often promoting proliferation (oncogenic role).
  • YAP can also bind tumor suppressors like RUNXs and p73, suggesting a tumor-suppressive role.

Conclusions:

  • YAP's function as an oncogene or tumor suppressor is determined by its binding partners.
  • The context-dependent activity of YAP/TAZ is critical for understanding their roles in health and disease.
  • Further research into YAP's interactions can reveal new therapeutic strategies for cancer.

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