[Granuloma formation in test and treatment sites caused by intracutaneously administered, injectable collagen]

Within 24 h of intracutaneous administration of an injectable collagen implant, a 34-year-old woman developed reddish-yellow nodules at two test implantation sites as well as at treatment sites. These nodules have persisted for more than 8 months. Histological findings seem to be consistent with an allergic reaction of the granulomatous type (type V).