Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Balancing Redox Equations02:58

Balancing Redox Equations

62.6K
Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
62.6K
Redox Reactions01:24

Redox Reactions

59.0K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
59.0K
Redox Reactions01:27

Redox Reactions

1.2K
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
1.2K
Metallic Solids02:37

Metallic Solids

20.9K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.9K
Structures of Solids02:22

Structures of Solids

18.8K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
18.8K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Key Common Genes with LTF and MMP9 Between Sepsis and Relapsed B-Cell Lineage Acute Lymphoblastic Leukemia in Children.

Biomedicines·2025
Same author

High-temperature strain measurement method based on scanning infrared signals.

Optics express·2025
Same author

Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Design, synthesis, and biological evaluation of liver-targeting phosphoric acid thyroid hormone receptor agonists for the treatment of metabolic dysfunction-associated steatohepatitis.

Bioorganic chemistry·2025
Same author

Sensitive and reliable micro-plate chemiluminescence enzyme immunoassay for okadaic acid in shellfish.

Analytical methods : advancing methods and applications·2025
Same author

Prognostic Risk Model of Megakaryocyte-Erythroid Progenitor (MEP) Signature Based on AHSP and MYB in Acute Myeloid Leukemia.

Biomedicines·2025

Related Experiment Video

Updated: Feb 15, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K

Redox-Responsive Amphipathic Dextran Nanomicelles for Solid Tumor Therapy.

Yanyan Song, Bo Lou, Jian Cheng

    Journal of Biomedical Nanotechnology
    |January 26, 2018
    PubMed
    Summary

    Researchers developed a novel dextran-based nanomicelle drug carrier that effectively delivers doxorubicin (DOX) to cancer cells. This system enhances antitumor efficacy and reduces toxicity, showing promise for improved cancer therapy.

    Keywords:
    Redox-ResponsiveDextranNanoparticlesMicellesDrug DeliverySolid Tumor

    More Related Videos

    Predictive Immune Modeling of Solid Tumors
    08:50

    Predictive Immune Modeling of Solid Tumors

    Published on: February 25, 2020

    7.6K
    Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging
    11:09

    Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging

    Published on: July 13, 2010

    40.5K

    Related Experiment Videos

    Last Updated: Feb 15, 2026

    Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
    08:34

    Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

    Published on: February 6, 2019

    21.2K
    Predictive Immune Modeling of Solid Tumors
    08:50

    Predictive Immune Modeling of Solid Tumors

    Published on: February 25, 2020

    7.6K
    Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging
    11:09

    Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging

    Published on: July 13, 2010

    40.5K

    Area of Science:

    • Biomaterials Science
    • Nanotechnology
    • Cancer Therapeutics

    Background:

    • Developing effective drug delivery systems is crucial for cancer therapy.
    • Doxorubicin (DOX) is a potent chemotherapeutic agent with limitations due to toxicity and drug resistance.
    • Novel carriers are needed to improve DOX delivery and efficacy.

    Purpose of the Study:

    • To synthesize and characterize a redox-responsive dextran-based nanomicelle for drug delivery.
    • To evaluate the efficacy of doxorubicin-loaded nanomicelles in vitro and in vivo.
    • To assess the potential of this system in overcoming drug resistance and reducing side effects.

    Main Methods:

    • Preparation of deoxycholic acid-grafted dextran (Dex-SSDCA) polymers.
    • Self-assembly of Dex-SSDCA into nanomicelles and encapsulation of doxorubicin (DOX).
    • In vitro studies using MCF-7/Adr cells and in vivo studies using SKOV-3 ovarian cancer models.
    • Assessment of drug release, cytotoxicity, tumor growth inhibition, angiogenesis, proliferation, apoptosis, and in vivo toxicity.

    Main Results:

    • Dex-SSDCA nanomicelles effectively encapsulated DOX and demonstrated rapid DOX release upon exposure to dithiothreitol (DTT).
    • DOX-loaded nanomicelles reversed drug resistance in MCF-7/Adr cells and inhibited their growth in vitro.
    • In vivo, DOX-loaded nanomicelles significantly suppressed tumor growth, reduced angiogenesis and proliferation, and increased apoptosis in SKOV-3 tumors.
    • The nanomicelles reduced DOX-induced side effects compared to free DOX.

    Conclusions:

    • Redox-responsive Dex-SSDCA nanomicelles are a promising drug carrier for enhancing antitumor efficiency.
    • This system effectively delivers DOX, overcomes drug resistance, and mitigates chemotherapy-induced toxicity.
    • Dex-SSDCA nanomicelles hold significant potential for advanced cancer therapy applications.