Related Experiment Video

Updated: Feb 15, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.5K

Multiple complications in sickle cell anaemia

Taimoor Khalid Janjua1, Syeda Amna Haider1, Naila Raza2

  • 1Liaquat National Medical College.

JPMA. the Journal of the Pakistan Medical Association
|January 27, 2018
PubMed

Insights

Sickle Cell Disease (SCD) in a male adolescent led to severe malnourishment, causing hemolytic anemia, ascites, hepatomegaly, and fractures. Early intervention and proper management are crucial to prevent life-threatening complications in homozygous SCD.

Area of Science:

  • Hematology
  • Genetics
  • Pediatrics

Background:

  • Sickle Cell Disease (SCD) is a genetic blood disorder characterized by abnormal hemoglobin.
  • It presents with diverse clinical manifestations and varying severity.
  • The homozygous form (HbSS) can lead to severe, life-threatening complications if not managed properly.

Observation:

  • A male adolescent with homozygous SCD presented with significant clinical issues.
  • Key observations included hemolytic anemia, massive ascites, and hepatomegaly.
  • Multiple fractures were also noted, indicative of severe underlying pathology.

Findings:

  • The patient's symptoms were directly linked to severe malnourishment.
  • Malnourishment exacerbated the effects of sickle cell disease, leading to organ damage and skeletal issues.
  • This case highlights the critical role of nutrition in managing SCD complications.

Implications:

  • This case underscores the importance of comprehensive care for homozygous SCD patients.
  • Aggressive nutritional support is vital to mitigate severe manifestations like organomegaly and fractures.
  • Improved management strategies are needed to prevent avoidable, life-threatening conditions in adolescents with SCD.

Keywords:
Hemoglobinopathies, Sickle cell anemia, Hepatomegaly.

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.4K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
38.2K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
998
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
917
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.4K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.4K
Multiple Regression01:25

Multiple Regression

Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
4.0K