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Updated: Feb 15, 2026
05:23
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
20.5K
Multiple complications in sickle cell anaemia.
Taimoor Khalid Janjua1, Syeda Amna Haider1, Naila Raza2
1Liaquat National Medical College.
JPMA. the Journal of the Pakistan Medical Association
|January 27, 2018
Summary
Sickle Cell Disease (SCD) in a male adolescent led to severe malnourishment, causing hemolytic anemia, ascites, hepatomegaly, and fractures. Early intervention and proper management are crucial to prevent life-threatening complications in homozygous SCD.
Area of Science:
- Hematology
- Genetics
- Pediatrics
Background:
- Sickle Cell Disease (SCD) is a genetic blood disorder characterized by abnormal hemoglobin.
- It presents with diverse clinical manifestations and varying severity.
- The homozygous form (HbSS) can lead to severe, life-threatening complications if not managed properly.
Observation:
- A male adolescent with homozygous SCD presented with significant clinical issues.
- Key observations included hemolytic anemia, massive ascites, and hepatomegaly.
- Multiple fractures were also noted, indicative of severe underlying pathology.
Findings:
- The patient's symptoms were directly linked to severe malnourishment.
- Malnourishment exacerbated the effects of sickle cell disease, leading to organ damage and skeletal issues.
- This case highlights the critical role of nutrition in managing SCD complications.
Implications:
- This case underscores the importance of comprehensive care for homozygous SCD patients.
- Aggressive nutritional support is vital to mitigate severe manifestations like organomegaly and fractures.
- Improved management strategies are needed to prevent avoidable, life-threatening conditions in adolescents with SCD.
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