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Related Concept Videos

Derivatives of Simple Functions01:27

Derivatives of Simple Functions

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Derivatives quantify the rate of change of a function and can be interpreted geometrically as the slope of a straight line or the slope of a tangent line to a curve at a given point. In the context of a roller coaster, the derivative of the function describing the track’s horizontal position provides a mathematical description of how steep the path is at any location along the ride.Constant and Linear PathsA horizontal segment of a roller coaster can be modeled by a constant function,...
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In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
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Amines to Amides: Acylation of Amines01:19

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Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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Genome Size and the Evolution of New Genes03:21

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Preparation of Amines: Alkylation of Ammonia and Amines01:30

Preparation of Amines: Alkylation of Ammonia and Amines

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Alkylation is one of the methods used to prepare amines. Direct alkylation of ammonia or a primary amine with an alkyl halide gives polyalkylated amines along with a quaternary ammonium salt through successive SN2 reactions. This process of making the quaternary salt through the direct alkylation method is called exhaustive alkylation.
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Functional Groups02:45

Functional Groups

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Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
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Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating
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Simple, Hackable, Size-Selective, Amine-Functionalized Fe-Oxide Nanoparticles for Biomedical Applications.

Palash Kumar Manna1, Rachel Nickel1, Yaroslav Wroczynskyj1

  • 1Department of Physics and Astronomy, University of Manitoba , Winnipeg, Manitoba R3T 2N2, Canada.

Langmuir : the ACS Journal of Surfaces and Colloids
|January 30, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a cost-effective method to create amine-functionalized iron oxide nanoparticles. These nanoparticles show high effectiveness against MRSA bacteria and potential for targeted drug delivery and hyperthermia in cancer treatment.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Iron oxide nanoparticles (Fe3O4) are crucial in biomedical applications.
  • Developing efficient and scalable synthesis methods for functionalized nanoparticles is essential.
  • Controlling nanoparticle morphology and surface chemistry is key for targeted applications.

Purpose of the Study:

  • To develop a facile, one-pot synthesis for amine-functionalized, nonspherical Fe3O4 nanoparticles.
  • To explore the potential biomedical applications of these synthesized nanoparticles.
  • To evaluate the antimicrobial and cellular uptake properties of the functionalized nanoparticles.

Main Methods:

  • One-pot synthesis using iron(II) chloride and triethylamine.
  • Morphological control via reaction temperature and amine concentration.
  • Surface modification for biocide coating and biocompatibility (EDTA-Na3).
  • Antimicrobial efficacy testing against MRSA.
  • Cellular uptake studies in U-251 glioblastoma cells under a DC magnetic field.

Main Results:

  • Gram-scale synthesis of amine-functionalized, nonspherical Fe3O4 nanoparticles achieved.
  • Biocide-coated nanoparticles demonstrated 100% MRSA deactivation within 2 hours.
  • EDTA-Na3-coated nanoparticles showed significant cellular uptake in U-251 cells with a magnetic field.
  • Particles are effective drug carriers for magnetic field-targeted delivery and hyperthermia.

Conclusions:

  • The developed method offers an economical and scalable route to functionalized Fe3O4 nanoparticles.
  • These nanoparticles exhibit potent antimicrobial activity.
  • The synthesized nanoparticles hold significant promise for targeted drug delivery and hyperthermia in cancer therapy.