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Updated: Feb 15, 2026
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
[Is there screening for urinary tuberculosis?]
S Yu Shevchenko1, E V Kulchavenya1
1Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia, 2Novosibirsk State Medical University of Minzdrav of Russia, Novosibirsk, Russia.
Introduction:
Most of the patients with genitourinary tuberculosis are detected too late. One of the reasons for this is the lack of a simple, cheap, reliable screening. The purpose of this study was to investigate the possibility of using a recombinant tuberculosis allergen (diaskintest) as a screening test to detect patients with genitourinary tuberculosis.
Material And Methods:
This is a simple prospective, open-label cohort study comprising 197 patients admitted to the Novosibirsk Research Institute of Tuberculosis for differential diagnosis in 2014-2016. Of then, 72 patients were found to have urogenital tuberculosis, while 125 patients had chronic nonspecific infections.
Results:
The sensitivity of the Kochs subcutaneous tuberculin test and the diaskintest was 80.4% and 63.8%, respectively. The specificity of the Kochs test was 91.5%, which makes it still possible to consider it essential in the differential diagnosis of urogenital tuberculosis and nonspecific urogenital infections. A high percentage of positive diaskintest results in patients with chronic infectious and inflammatory diseases of the genitourinary system caused a low specificity of the test - 37.5%.
Conclusion:
Diaskintest can be used in screening for genitourinary tuberculosis, but its positive result indicative for diagnosis. It may be used only as a reason for in-depth phthisiourological examination using additional provocative tests, in particular, Kochs test, which showed high diagnostic performance.
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