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Updated: Feb 15, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

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[Is there screening for urinary tuberculosis?]

S Yu Shevchenko1, E V Kulchavenya1

  • 1Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia, 2Novosibirsk State Medical University of Minzdrav of Russia, Novosibirsk, Russia.

Urologiia (Moscow, Russia : 1999)
|January 30, 2018
PubMed
Summary
This summary is machine-generated.

Diaskintest shows potential for screening genitourinary tuberculosis but lacks specificity. The Kochs test remains essential for differential diagnosis of genitourinary tuberculosis and infections.

Keywords:
diagnosticsdiaskintestdifferential diagnosisscreeningtuberculinurinary tract infectionsurogenital tuberculosis

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Area of Science:

  • Urology
  • Infectious Diseases
  • Immunology

Background:

  • Genitourinary tuberculosis (GUTB) diagnosis is often delayed due to the absence of effective screening methods.
  • Current diagnostic approaches for GUTB lack simplicity, affordability, and reliability.

Purpose of the Study:

  • To evaluate the efficacy of Diaskintest, a recombinant tuberculosis allergen, as a screening tool for detecting genitourinary tuberculosis.
  • To compare the diagnostic performance of Diaskintest with the Kochs tuberculin test in patients with genitourinary conditions.

Main Methods:

  • A prospective, open-label cohort study involving 197 patients undergoing differential diagnosis at the Novosibirsk Research Institute of Tuberculosis.
  • Patients were categorized into two groups: 72 with confirmed urogenital tuberculosis and 125 with chronic nonspecific infections.

Main Results:

  • Diaskintest demonstrated a sensitivity of 63.8% and a low specificity of 37.5% for genitourinary tuberculosis.
  • The Kochs tuberculin test exhibited higher diagnostic performance with 80.4% sensitivity and 91.5% specificity.
  • A significant number of positive Diaskintest results were observed in patients with chronic inflammatory genitourinary diseases, impacting its specificity.

Conclusions:

  • Diaskintest can serve as an initial screening tool for genitourinary tuberculosis, warranting further investigation.
  • A positive Diaskintest result should prompt in-depth phthisiourological examination, potentially including provocative tests like the Kochs test.
  • The Kochs test remains a crucial diagnostic tool for differentiating genitourinary tuberculosis from nonspecific urogenital infections due to its high specificity.