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How to Control Asthma with Personalized Management: Where Do We Stand Now?
Meng Wang1,2,3, Yuan Yao1,2,3, Shanqun Jiang4
1Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100730, Beijing, China.
Current Drug Metabolism
|January 31, 2018
Summary
Personalized asthma therapy, guided by genetic testing, can predict treatment responses for better patient management. This precision medicine approach paves the way for future preventive and predictive strategies in asthma care.
Area of Science:
- Pharmacogenetics
- Precision Medicine
- Asthma Research
Background:
- Asthma is a significant global health issue with substantial physical and economic burdens.
- Phenotypic variations in asthma necessitate personalized treatment strategies.
- Pharmacogenetics and precision medicine trials are increasingly exploring tailored asthma therapies.
Purpose of the Study:
- To review and summarize genetic loci associated with drug responses in asthma.
- To identify key treatments and their pharmacogenetic underpinnings.
- To assess the potential of genetic testing for personalized asthma management.
Main Methods:
- Systematic literature retrieval from MEDLINE (Ovid) and PubMed.
- Screening and inclusion of relevant publications.
- Focus on β-adrenergic receptor agonists, inhaled corticosteroids (ICS), and anti-leukotriene modifiers.
Main Results:
- 36 studies met inclusion criteria, focusing on common asthma medications.
- Identified genetic loci potentially influencing patient response to treatments.
- Summarized existing literature on pharmacogenetics of asthma pharmacotherapy.
Conclusions:
- Genetic testing shows high predictive accuracy for therapeutic responses in asthma.
- Personalized management strategies can be achieved through genetic insights.
- This approach supports the future of personalized preventive and predictive medicine for asthma.
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