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Intralesional Bleomycin Injection for Propranolol-Resistant Hemangiomas
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
The Journal of Craniofacial Surgery
|January 31, 2018
Summary
Propranolol is a common treatment for hemangiomas, but some cases resist it. Intralesional bleomycin injections offer a stable alternative for propranolol-resistant hemangiomas, showing promise in clinical observation.
Area of Science:
- Dermatology
- Pediatric Surgery
- Vascular Anomalies
Background:
- Propranolol is the standard first-line therapy for infantile hemangiomas.
- A subset of hemangiomas exhibit resistance to propranolol treatment.
- Alternative therapeutic strategies are needed for propranolol-resistant cases.
Observation:
- A case of propranolol-resistant hemangioma was treated with intralesional bleomycin injections.
- The hemangioma demonstrated stability for 16 months following three bleomycin injections.
- Ultrasonic monitoring was employed to investigate the mechanism of action.
Findings:
- Intralesional bleomycin injections led to sustained stability in a propranolol-resistant hemangioma.
- The treatment was effective in managing a challenging case unresponsive to standard therapy.
- Ultrasonic findings provided insights into the therapeutic effects of bleomycin.
Implications:
- Intralesional bleomycin injection presents a viable and effective treatment option for propranolol-resistant hemangiomas.
- This approach may offer a solution for patients who do not respond to or tolerate propranolol.
- Further research into bleomycin's mechanism in hemangioma treatment is warranted.
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