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Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
Published on: March 29, 2018
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Bone regeneration with recombinant human bone morphogenetic protein 2: a systematic review
Jannice de Queiroz Fernandes1, Valthierre Nunes de Lima2, João Paulo Bonardi2
1Quixadaense Post Graduate School, Rodrigues Junior Street, Number 1034, Quixadá, Ceara CEP 63900-000 Brazil.
Journal of Maxillofacial and Oral Surgery
|February 1, 2018
Summary
Recombinant human bone morphogenetic protein-2 (rhBMP-2) shows an 81.4% success rate for bone regeneration, making dental implant placement feasible. This review confirms rhBMP-2 as a satisfactory option for bone reconstruction.
Area of Science:
- Regenerative Medicine
- Oral Surgery
- Biomaterials
Background:
- Bone defects pose challenges for dental implant placement.
- rhBMP-2 is a potent osteoinductive factor investigated for bone regeneration.
Purpose of the Study:
- To systematically review the clinical efficacy of rhBMP-2 in bone reconstruction for dental implants.
- To assess the success rates and adverse events associated with rhBMP-2 use.
Main Methods:
- Systematic literature review of clinical trials.
- PUBMED database search.
- Inclusion of nine selected clinical trials.
Main Results:
- Successful bone regeneration achieved in 81.4% of cases using rhBMP-2.
- Implant placement success rate was 87.4% in rhBMP-2 regenerated bone.
- Common adverse events included pain, edema, and erythema.
Conclusions:
- rhBMP-2 treatment is satisfactory for bone reconstruction prior to dental implants.
- Dental implant placement in rhBMP-2 regenerated bone is a feasible clinical option.
- Further research may explore optimizing rhBMP-2 application and managing side effects.
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