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Characterization of the novel HLA-C*16:116 allele by sequencing-based typing
G Guidicelli1, V Elsermans2, I Top2
1CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Bordeaux, France.
HLA
|February 2, 2018
Summary
A novel Human Leukocyte Antigen C (HLA-C) allele, HLA-C*16:116, has been identified. This new allele is distinguished from HLA-C*16:01:01:01 by a single nucleotide substitution.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The Human Leukocyte Antigen (HLA) system plays a critical role in immune response.
- Polymorphisms in HLA genes, particularly HLA-C, contribute to immune diversity and disease susceptibility.
Purpose of the Study:
- To report the discovery and initial characterization of a novel HLA-C allele.
Main Methods:
- Sequence analysis of HLA-C gene regions.
- Comparison with known HLA allele sequences.
Main Results:
- Identification of a new allele, designated HLA-C*16:116.
- The novel allele differs from HLA-C*16:01:01:01 by a single nucleotide substitution at position 30.
Conclusions:
- The discovery of HLA-C*16:116 expands the known HLA-C allele repertoire.
- This finding contributes to a more comprehensive understanding of HLA polymorphism.
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