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[Testicular function during prolonged corticotherapy].

J M Kuhn, D Gay, J P Lemercier

    Presse Medicale (Paris, France : 1983)
    |March 22, 1986
    PubMed
    Summary
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    Prolonged glucocorticoid treatment in men can lead to decreased testosterone levels and impaired testicular function, potentially causing hypoandrogenism. This study investigated the effects of steroidal anti-inflammatory agents on male reproductive health.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Pharmacology

    Context:

    • Corticosteroid therapy is widely used but can cause protein catabolism.
    • Short-term ACTH or glucocorticoid treatment in males lowers plasma testosterone.
    • The origin of this hypogonadism requires further investigation.

    Purpose:

    • To investigate testicular function in men undergoing prolonged glucocorticoid treatment.
    • To determine the effects of steroidal anti-inflammatory agents on male reproductive hormones.

    Summary:

    • Men treated with glucocorticoids for over 2 years showed significantly lower plasma testosterone levels compared to controls.
    • Luteinizing hormone levels were elevated in short-term treated patients but normal in long-term treated patients.

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  • Testosterone levels correlated negatively with glucocorticoid dosage, and testicular response to hCG was reduced.

    • Impact:

    • Prolonged glucocorticoid use impacts both gonadotrophic and testicular function.
    • This can lead to true hypoandrogenism in men.
    • Findings suggest careful monitoring of reproductive health in patients on long-term corticosteroid therapy.