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Lupus nephritis with preserved kidney function associated with poorer cardiovascular risk control: A call for more

J A Todolí-Parra1, Y Tung-Chen2, L Micó1

  • 1Department of Internal Medicine, University and Polytechnic Hospital La Fe, Valencia, Spain.

Hipertension Y Riesgo Vascular
|February 4, 2018
PubMed

Insights

Patients with lupus nephritis have high cardiovascular risk factors, even with healthy kidneys. Early intervention and closer management are crucial for managing lupus nephritis and reducing cardiovascular complications.

Area of Science:

  • Rheumatology
  • Cardiology
  • Nephrology

Background:

  • Systemic lupus erythematosus (SLE) patients face high cardiovascular morbidity and mortality.
  • Lupus nephritis (LN) management aims for remission while minimizing medication side effects.
  • Early recognition and management of flares are essential.

Purpose of the Study:

  • To assess cardiovascular (CV) risk profiles in SLE patients with preserved kidney function post-nephritis.
  • To compare CV risk in SLE patients with and without a history of nephritis flares.

Main Methods:

  • A cohort of 130 SLE patients (32 with prior nephritis, 98 without) was studied.
  • Cardiovascular risk factors were evaluated despite preserved renal function.

Main Results:

  • Sedentary lifestyle, overweight/obesity, and dyslipidemia were prevalent CV risk factors.
  • Patients with prior nephritis flares showed significantly higher rates of dyslipidemia, smoking, left ventricular hypertrophy (LVH), and lower HDL-C.
  • Younger LN patients on intensive treatment had a greater aggregation of CV risk factors.

Conclusions:

  • SLE patients with a history of nephritis have poor CV risk factor control, even with normal kidney function.
  • These patients require intensified therapeutic management to mitigate CV risks.
Abstract

Keywords:
Cardiovascular diseaseEnfermedad cardiovascularLupus eritematoso sistémicoLupus nephritisNefropatía lúpicaSystemic lupus erythematosus

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