MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial

Area of Science:

• Ophthalmology
• Pediatric Optometry
• Myopia Control Research

Background:

• Myopia, or nearsightedness, is a growing global health concern in children.
• Effective myopia control strategies are crucial to prevent high myopia and associated ocular complications.
• Current interventions include spectacle lenses, contact lenses, and atropine eye drops.

Purpose of the Study:

• To compare the efficacy of MiSight contact lenses (CLs) versus single-vision (SV) spectacles in controlling myopia progression over a 2-year period in children.
• To evaluate the impact of these interventions on axial elongation, a key indicator of myopia progression.

Main Methods:

• A randomized clinical trial involving 89 children aged 8-12 with myopia and low astigmatism.
• Participants were assigned to either MiSight CLs or SV spectacles.
• Ocular measurements including visual acuity, refraction, and axial length were recorded at baseline and 6-month intervals for 2 years.

Main Results:

• After 2 years, children wearing MiSight CLs exhibited significantly slower myopia progression (0.45 D) compared to those in the SV group (0.74 D).
• Axial elongation was also significantly reduced in the MiSight group (0.28 mm) versus the SV group (0.44 mm).
• MiSight CLs demonstrated a 39.32% reduction in myopia progression and a 36.04% reduction in axial growth.

Conclusions:

• MiSight contact lens wear is effective in reducing both myopia progression and axial elongation in children compared to standard single-vision spectacles.
• These findings support the use of MiSight CLs as a viable myopia management option for pediatric patients.
• The study provides robust clinical evidence for a specific contact lens design in myopia control.