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Superior bone-inducing potential of rhBMP9 compared to rhBMP2
Masako Fujioka-Kobayashi1, Mustafa Abd El Raouf2,3, Nikola Saulacic1
1Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Journal of Biomedical Materials Research. Part A
|February 4, 2018
Summary
Recombinant human bone morphogenic protein 9 (rhBMP9) shows greater potential for bone regeneration than rhBMP2, even at lower doses. This study confirms rhBMP9
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedics
Background:
- Recombinant human bone morphogenic proteins (rhBMPs) are crucial for bone regeneration.
- rhBMP9 has shown promising osteopromotive potential in vitro compared to rhBMP2.
Purpose of the Study:
- To investigate and compare the bone-inducing potential of rhBMP2 and rhBMP9 in vitro and in vivo.
- To evaluate the efficacy of rhBMP9 in ectopic bone formation and calvarial defect repair.
Main Methods:
- In vitro comparison of rhBMP2, rhBMP7, and rhBMP9 at various concentrations for osteoblast differentiation.
- In vivo studies using atelo-collagen membranes and deproteinized bovine bone mineral (DBBM) in rabbit calvarial defects.
- Assessment of new bone formation using micro-CT and histological analysis.
Main Results:
- rhBMP9 demonstrated significantly greater osteogenic potential than rhBMP2 in vitro, even at 20 times lower concentrations.
- Noggin, an inhibitor of rhBMP2, did not affect rhBMP9-induced osteogenesis.
- In vivo, rhBMP9 loaded onto atelo-collagen membranes and DBBM showed comparable or superior bone regeneration compared to rhBMP2 at four times lower doses.
Conclusions:
- rhBMP9 is a potent osteoinductive agent capable of inducing ectopic bone formation.
- rhBMP9 offers a potentially more effective and dose-sparing alternative to rhBMP2 for bone regeneration applications.
- Lower doses of rhBMP9 can achieve comparable or enhanced bone regeneration in critical-sized defects.
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