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Induction of fragile sites in fibroblasts

G R Sutherland, E Baker

American Journal of Human Genetics

|April 1, 1986

Abstract:

A simple, reliable method for the induction of folate-sensitive fragile sites, including the fragile X, in fibroblasts is described. The method involves only the addition of 600 mg/l thymidine to cultures 24 hrs before they are harvested.

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