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Transferability of MCR-1/2 Polymyxin Resistance: Complex Dissemination and Genetic Mechanism

Youjun Feng1,2

  • 1Department of Medical Microbiology and Parasitology , Zhejiang University School of Medicine , Hangzhou , Zhejiang 310058 , China.

ACS Infectious Diseases
|February 6, 2018
PubMed

Insights

The mobilized colistin resistance determinant mcr-1 is spreading globally, threatening infections caused by carbapenem-resistant Gram-negative pathogens. This review details mcr-1

Area of Science:

  • Microbiology
  • Genetics
  • Public Health

Background:

  • Polymyxins are critical last-resort antibiotics against multidrug-resistant Gram-negative bacteria.
  • The emergence and rapid spread of the mobilized colistin resistance determinant 1 (mcr-1) gene pose a significant threat to global health.
  • Colistin resistance compromises treatment options for severe Gram-negative infections, impacting both clinical settings and agriculture.

Purpose of the Study:

  • To provide an updated overview of the mobilized colistin resistance determinant 1 (mcr-1).
  • To cover the global dissemination, host range, and genetic environment of mcr-1.
  • To discuss new mcr-like genes and the molecular mechanisms of MCR-1/2.

Main Methods:

  • Mini-review synthesizing current scientific literature.
  • Analysis of global surveillance data on mcr-1 prevalence.
  • Examination of genetic elements associated with mcr-1 and related genes.

Main Results:

  • MCR-1 has disseminated globally across diverse Gram-negative bacterial species.
  • MCR-1 is frequently located on mobile genetic elements, particularly plasmids, facilitating its spread.
  • New variants and related genes (e.g., mcr-2) are emerging, indicating ongoing evolution of colistin resistance.

Conclusions:

  • The widespread dissemination of mcr-1 necessitates urgent global surveillance and control strategies.
  • Understanding the genetic context of mcr-1 is crucial for developing effective interventions.
  • Continued research into novel polymyxin derivatives and alternative therapies is essential.
Keywords:
MCR-1colistin resistanceglobal disseminationmcr-like genesplasmid reservoir

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