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Updated: Feb 15, 2026

MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium
Published on: June 24, 2014
[Differential Expression Profiles of MicroRNAs between de novo and Complete Response Severe Aplastic Anemia]
Ying-Qi Shao1, Hong-Yu Dong2, Mei-Li Ge1
1State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Objective:
To detect the expression of miRNA in de novo and complete response SAA patients and predict the targets of the miRNAs.
Methods:
The expression profiles of miRNA from bone marrow mononuclear cells of the SAA patients with de novo and CR were detected by miRNA microarray.
Results:
Totally 35 up-regulated and 37 down-regulated miRNA were identified in CR SAA patients in comparison with de novo SAA patients. Furthermore, by predicting the targets of the differentlly expressed miRNA, it was found that some targets associated with T cell receptor signaling pathway and cell adhesion molecules.
Conclusion:
Some miRNA may be involved in the pathogenesis of SAA.
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