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Pseudomembranous colitis caused by topical clindamycin phosphate.

M F Parry, C K Rha

Archives of Dermatology

|May 1, 1986

Summary

Topical clindamycin phosphate caused recurrent pseudomembranous colitis in a patient. Treatment with oral vancomycin and clindamycin withdrawal resolved the condition.

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Area of Science:

Medicine
Microbiology
Pharmacology

Background:

Pseudomembranous colitis is a severe gastrointestinal condition often linked to antibiotic use.
Clostridium difficile is a common pathogen implicated in antibiotic-associated colitis.

Observation:

A patient experienced two episodes of pseudomembranous colitis.
Both colitis episodes were associated with the topical application of clindamycin phosphate.

Findings:

Clostridium difficile toxin assays were positive in both instances.
Successful treatment involved oral vancomycin hydrochloride and discontinuation of clindamycin therapy.

Implications:

This case highlights the potential for topical clindamycin to induce pseudomembranous colitis.
It underscores the importance of considering antibiotic-associated colitis even with non-systemic drug administration.
Vancomycin remains an effective treatment for Clostridium difficile infections.

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