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Related Experiment Video

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Creating Avian Forebrain Chimeras to Assess Facial Development

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Published on: February 18, 2021

The Basal Forebrain Regulates Global Resting-State fMRI Fluctuations.

Janita Turchi¹, Catie Chang², Frank Q Ye³

¹Laboratory of Neuropsychology, NIMH, NIH, NIH, Bethesda, MD 20892 USA.

|February 6, 2018

Summary

The nucleus basalis of Meynert (NBM) selectively impacts global brain activity patterns, not specific resting-state networks. This study reveals the NBM's role in coordinating widespread brain fluctuations.

Keywords:

arousal basal forebrain cerebral cortex fMRI functional connectivity global signal macaque nucleus basalis ongoing activity resting-state networks

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Area of Science:

Neuroscience
Functional Neuroimaging

Background:

Spontaneous brain activity, measured by fMRI, reveals functional organization but underlying mechanisms are unclear.
The nucleus basalis of Meynert (NBM) is a key source of cholinergic and GABAergic projections to the cortex.

Purpose of the Study:

To investigate the hypothesis that the NBM critically contributes to spontaneous brain activity patterns.
To elucidate the NBM's role in generating and coordinating neural fluctuations.

Main Methods:

Reversible inactivation of two distinct NBM sites in macaques.
Simultaneous measurement of whole-brain fMRI activity.

Main Results:

NBM inactivation caused significant, localized suppression of global signal components in the ipsilateral cortex.
Resting-state networks maintained their spatial structure despite the suppression of global signals.

Conclusions:

The NBM selectively contributes to the global component of functional connectivity.
The NBM plays a minimal role in the specific correlations defining resting-state networks.