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[Circulating and basophil-fixed specific IgE in human alveolar echinococcosis]
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1985
Summary
Immediate hypersensitivity in alveolar echinococcosis involves elevated total and parasite-specific IgE. Specific IgE levels correlated with parasite removal, not mebendazole treatment, and were detected even in serologically negative patients.
Area of Science:
- Immunology
- Parasitology
- Infectious Diseases
Context:
- Alveolar echinococcosis is a severe parasitic infection.
- Immediate type hypersensitivity plays a role in host immune responses.
- Understanding immune markers is crucial for diagnosis and monitoring.
Purpose:
- To investigate biological parameters of immediate type hypersensitivity in alveolar echinococcosis patients.
- To assess the relationship between total IgE, parasite-specific IgE, and clinical outcomes.
- To evaluate the presence of specific IgE on basophils.
Summary:
- 19 patients with alveolar echinococcosis were studied for immediate hypersensitivity markers.
- Elevated serum total IgE was found in 12 patients, and parasite-specific IgE in 9, with a significant correlation between them.
- Specific IgE levels decreased after parasitic material removal but not with mebendazole treatment.
- Specific basophil-fixed IgE was detected in all patients, including those serologically negative for circulating specific IgE.
Impact:
- This study highlights the role of IgE in alveolar echinococcosis.
- Findings suggest specific IgE levels can serve as a marker for parasitic material burden.
- The detection of specific IgE on basophils in all patients warrants further investigation for diagnostic and therapeutic implications.