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Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells.
Marthe F S Lindenbergh1, Willem Stoorvogel1
1Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, NL-3508 TD Utrecht, The Netherlands;
Annual Review of Immunology
|February 6, 2018
Summary
Extracellular vesicles (EVs) mediate immune cell communication, transferring signals to regulate adaptive immunity. These vesicles, particularly from antigen-presenting cells, show promise for cancer immunotherapy.
Area of Science:
- Immunology
- Cell Biology
- Biotechnology
Background:
- Adaptive immunity relies on complex cell-cell communication.
- Extracellular vesicles (EVs), including exosomes, are key mediators of this communication.
- EVs transfer specific signaling molecules between immune cells.
Purpose of the Study:
- To review the roles of EVs in adaptive immunity.
- To focus on EVs derived from antigen-presenting cells (APCs).
- To explore the potential of EVs in cancer immunotherapy.
Main Methods:
- Literature review of existing studies on EVs and adaptive immunity.
- Analysis of mechanisms of EV formation and targeting.
- Examination of APC-derived EVs and their functions.
Main Results:
- EVs are released by most immune cells and influence immune responses.
- EVs facilitate the initiation, expansion, maintenance, and silencing of adaptive immunity.
- APCs extensively utilize EVs for immune modulation.
Conclusions:
- EVs are crucial for intercellular communication in adaptive immunity.
- APCs-derived EVs have significant roles in immune regulation.
- EVs represent a promising avenue for developing novel cancer immunotherapies.
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