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A Novel Flavonoid Glucoside from the Fruits of Lycium ruthenicun
Jing-Jing Qi1,2, Yong-Ming Yan3, Li-Zhi Cheng4
1School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China. qijing023@163.com.
Abstract:
A novel flavonoid glucoside, ruthenicunoid A (1), together with eight known substances, were isolated from the fruits of Lycium ruthenicun Murr. Their structures were elucidated by extensive spectroscopic data and chemical methods. Especially, the absolute configuration of glucose residue in 1 was assigned by acid hydrolysis followed by derivatization and GC analysis. Biological evaluation towards Sirtuin 1 (SIRT1) found that compounds 1 and 2 exhibit inhibitory activity against SIRT1 in a concentration-dependent manner, indicating its potential on SIRT1-associated disorders.
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