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Determination of Carbonyl Functional Groups in Bio-oils by Potentiometric Titration: The Faix Method
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Determination of pKa values of alendronate sodium in aqueous solution by piecewise linear regression based on

Jing Ke1, Hanfei Dou1, Ximin Zhang2

  • 1Institute of Pharmaceutical Analysis, School of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000, China.

Journal of Pharmaceutical Analysis
|February 7, 2018
PubMed

Keywords:
Acid-base potentiometric titrationAlendronate sodiumDissociation constantsDistribution curvePiecewise linear regression

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A titration is carried out for 25.00 mL of 0.100 M HCl (strong acid) with 0.100 M of a strong base NaOH. The pH at different volumes of added base solution can be calculated as follows:
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