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Data Collection on Marine Litter Ingestion in Sea Turtles and Thresholds for Good Environmental Status
Published on: May 18, 2019
The turtle and the rabbit story in a modern (PI3)key
Miriam Martini1, Maria Chiara De Santis1, Emilio Hirsch1
1Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Torino, Italy.
Abstract:
Mitosis is a complex process controlling proper distribution of chromosomes and preventing genomic instability, a typical hallmark of cancer. We recently reported that that a class II isoform of Phosphoinositide 3-kinase (PI3K), PI3K-C2α, is involved in the organization of the mitotic spindle. Our study demonstrate that, differently to all other PI3K isoforms, PI3K-C2α shows an unexpected tumor suppressor function independent of its catalytic activity.
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