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The Growing Threat of Antibiotic Resistance in Children

Rachel L Medernach1, Latania K Logan1

  • 1Department of Pediatrics, Rush Medical College, Rush University Medical Center, 1710 W. Harrison Street, Suite 710 POB, Chicago, IL 60612, USA.

Infectious Disease Clinics of North America
|February 7, 2018
PubMed

Insights

Antimicrobial resistance poses a global threat, particularly impacting children with rising drug-resistant infections. This review examines clinical and molecular data on antibiotic-resistant bacteria in pediatric populations, focusing on transmission and horizontal gene transfer.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Microbiology

Background:

  • Antimicrobial resistance (AMR) is a significant global health crisis.
  • The escalating threat of drug-resistant infections affects all age groups.
  • Pediatric infections caused by antibiotic-resistant bacteria have been underrecognized.

Purpose of the Study:

  • To review current clinical and molecular data on antibiotic-resistant bacterial infections in children.
  • To emphasize the mechanisms of transmissible resistance in pediatric populations.
  • To highlight the role of horizontal gene transfer in the spread of resistance.

Main Methods:

  • Literature review of clinical data.
  • Analysis of molecular data on antibiotic resistance.
  • Focus on pediatric case studies and epidemiological trends.

Main Results:

  • Increasing incidence of infections caused by antibiotic-resistant bacteria in infants and children.
  • Identification of key resistant pathogens affecting pediatric populations.
  • Evidence of horizontal gene transfer facilitating resistance spread.

Conclusions:

  • Pediatric antimicrobial resistance is a growing concern requiring focused attention.
  • Understanding transmission dynamics, including horizontal gene transfer, is crucial for intervention.
  • Clinical and molecular surveillance in children is essential to combat this public health threat.

Keywords:
BacteriaChildDrug resistanceEpidemiologyGenetic structuresInfectionPublic healthβ-Lactamases

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