Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of an objective comedogenicity assay.

S B Tucker, S A Flannigan, M Dunbar

    Archives of Dermatology
    |June 1, 1986
    PubMed
    Summary

    This study introduces an objective rabbit ear assay for assessing skin product safety. It measures follicular orifice size, offering a more reliable alternative to subjective grading methods for comedogenicity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Trends in lung cancer diagnosis and care among visible minorities and non-visible minorities in Canada.

    Cancer causes & control : CCC·2023
    Same author

    Big data from small animals: integrating multi-level environmental data into the Dog Aging Project.

    Revue scientifique et technique (International Office of Epizootics)·2023
    Same author

    Perinatal Stroke in Fetuses, Preterm and Term Infants.

    Seminars in pediatric neurology·2022
    Same author

    Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial.

    Annals of oncology : official journal of the European Society for Medical Oncology·2022
    Same author

    Sociodemographic predictors of attendance at a Scottish pain management programme.

    British journal of pain·2021
    Same author

    Supply of care by dental therapists and emergency dental consultations in Alaska native communities in the Yukon-Kuskokwim delta: a mixed methods evaluation.

    Community dental health·2020

    Area of Science:

    • Dermatology
    • Toxicology
    • Cosmetic Science

    Background:

    • The rabbit ear assay is a standard for evaluating skin product safety.
    • Existing methods face reliability issues due to subjective grading and inter-laboratory variability.
    • There is a need for more objective and reproducible assays.

    Purpose of the Study:

    • To develop and validate a more objective rabbit ear comedogenicity assay.
    • To improve the reliability and reproducibility of comedogenicity testing.
    • To establish a quantitative measure of comedogenic activity.

    Main Methods:

    • Utilized an objective assay measuring follicular orifice size on rabbit ears.
    • Employed a noninvasive Silastic elastomer mold for serial measurements.
    • Applied test agents over a four-week period.

    Main Results:

    • Demonstrated a generally linear increase in follicular orifice area with tested agents.
    • Showed that follicular orifice size correlates with comedogenic potential.
    • The mold allowed for consistent measurement of the same sites over time.

    Conclusions:

    • The objective follicular orifice size assay provides a reliable method for assessing comedogenicity.
    • This quantitative approach overcomes limitations of subjective grading.
    • The assay is valuable for screening cosmetic and dermatological agents.

    Related Experiment Videos