Related Experiment Video
Updated: Jul 29, 2026
06:16
LipidUNet-Machine Learning-Based Method of Characterization and Quantification of Lipid Deposits Using iPSC-Derived Retinal Pigment Epithelium
Published on: July 28, 2023
Abnormal retinal function associated with isotretinoin therapy for acne.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 1, 1986
Summary
Isotretinoin, used for cystic acne, can cause vision problems like poor night vision. Some patients experienced lasting retinal function changes, including abnormal dark adaptation and electroretinograms (ERGs).
Area of Science:
- Ophthalmology
- Dermatology
- Retinal Physiology
Background:
- Isotretinoin is a common treatment for severe cystic acne.
- Potential ocular side effects of isotretinoin are a concern.
Observation:
- Three out of 50 patients on isotretinoin reported poor night vision or glare sensitivity.
- Abnormal dark adaptation and electroretinograms (ERGs) were observed in some patients during or after treatment.
Findings:
- Two patients showed abnormal dark adaptation, with elevated cone or rod thresholds.
- Abnormal ERGs and electro-oculograms were noted; some abnormalities persisted for over a year.
- Analysis suggested reduced retinal sensitivity and response compression in ERG parameters.
Implications:
- Isotretinoin may interfere with normal retinol binding, affecting retinal function.
- These findings highlight the need for monitoring visual function in patients treated with isotretinoin.
- Further prospective studies are needed to confirm the frequency of these visual adverse effects.
Related Concept Videos
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...