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Putative major histocompatibility complex (MHC) class II-specific T cell clones were isolated from nominal antigen-primed T cell populations propagated in vitro under antigen selection. However, unlike the proliferative responses of nominal antigen-specific, MHC class II-restricted T cell clones derived from the same population, the former's MHC-specific proliferative responses required that the culture medium be supplemented with serum. The role of xenogeneic antigens in the generation of this category of "autoreactive" T cells is discussed.
Putative major histocompatibility complex (MHC) class II-specific T cell clones were isolated from nominal antigen-primed T cell populations propagated in vitro under antigen selection. However, unlike the proliferative responses of nominal antigen-specific, MHC class II-restricted T cell clones derived from the same population, the former's MHC-specific proliferative responses required that the culture medium be supplemented with serum. The role of xenogeneic antigens in the generation of this category of "autoreactive" T cells is discussed.