Related Experiment Video
Updated: Feb 14, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE?
Chao You1, Anna K Kaiser2, Pascal Baltzer3
1Department of Radiology, Fudan University Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University.
Objective:
To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM).
Methods:
146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to the high-risk cases on the basis of age. The correlation of BPE with factors such as fibroglandular tissue (FGT), age, menopausal status, breast cancer, high-risk precondition as well as motion were investigated using linear regression.
Results:
BPE positively correlated with FGT (P<.001) and negatively correlated with menopausal status (P<.001). Cancer did not show an effect on BPE (P>.05). A high-risk precondition showed a significant impact on the formation of BPE (P<.05). However, when corrected for motion, the correlation between BPE and a high-risk precondition became weak and insignificant, and a highly significant association between BPE and motion was revealed (P<.01).
Conclusion:
BPE positively correlated with FGT and negatively correlated with age. Cancer did not have an effect on BPE. A high-risk precondition appears to have a negative effect on BPE. However, when corrected for motion, high-risk preconditions became insignificant. Technical as well as physiological influences seem to play an important role in the formation of BPE.
More Related Videos
Related Concept Videos
Conservation of Small Populations
Design Example: Analyzing Capacity Contours for Flood Risk Assessment
What is Population Genetics?
Population Growth
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...

