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Stable Liquid Glucagon: Beyond Emergency Hypoglycemia Rescue
Leah M Wilson1, Jessica R Castle1
11 Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, OR, USA.
Journal of Diabetes Science and Technology
|February 9, 2018
Summary
Stable liquid glucagon is needed for type 1 diabetes management. Improved formulations will enhance treatment for hypoglycemia and support advanced diabetes technologies, improving patient quality of life.
Area of Science:
- Endocrinology and Metabolism
- Pharmaceutical Sciences
Background:
- Glycemic control is crucial for preventing diabetes complications but increases hypoglycemia risk.
- Severe hypoglycemia significantly impairs quality of life and can be fatal for type 1 diabetes patients.
- Current glucagon emergency kits are effective but complex for untrained users.
Purpose of the Study:
- To review current and upcoming pharmaceutical uses of glucagon in type 1 diabetes treatment.
- To highlight the need for stable liquid glucagon formulations.
- To discuss the potential benefits of stable liquid glucagon for various hypoglycemia treatments.
Main Methods:
- Literature review of pharmaceutical uses of glucagon.
- Analysis of existing glucagon delivery devices and formulations.
- Discussion of future directions for stable liquid glucagon development.
Main Results:
- Existing glucagon emergency kits present usability challenges.
- A stable liquid glucagon formulation is lacking despite advances in insulin.
- Stable liquid glucagon could enable wider use of mini-dose glucagon and closed-loop systems.
Conclusions:
- There is a significant need for stable liquid glucagon preparations.
- Availability of stable liquid glucagon would improve hypoglycemia management in type 1 diabetes.
- Future research and development should focus on creating stable liquid glucagon for patient use.
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