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Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Feb 14, 2026

Author Spotlight: Exploring the Complexities of Achilles Tendon Injuries — Research and Future Directions

Author Spotlight: Exploring the Complexities of Achilles Tendon Injuries — Research and Future Directions

Published on: October 27, 2023

ACTN3, Morbidity, and Healthy Aging.

Craig Pickering^1,2, John Kiely¹

¹Institute of Coaching and Performance, School of Sport and Wellbeing, University of Central Lancashire, Preston, United Kingdom.

Frontiers in Genetics

|February 9, 2018

Summary

The ACTN3 gene variant impacts muscle function and bone density in older adults. Understanding this genetic factor can personalize health strategies and exercise programs for improved aging.

Keywords:

ACTN3 aging bone mineral density genetics personalized sarcopenia

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Last Updated: Feb 14, 2026

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Published on: October 27, 2023

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Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

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Published on: August 20, 2013

Area of Science:

Gerontology
Human Genetics
Exercise Physiology

Background:

Increasing human longevity necessitates research into maintaining health in old age.
Loss of muscle mass in the elderly is linked to sarcopenia and reduced bone mineral density.
The ACTN3 gene is known to influence muscle performance in athletes.

Purpose of the Study:

To review the impact of a specific ACTN3 gene polymorphism on elderly muscle function, bone mineral density, and metabolic disorder risk.
To assess the ACTN3 genotype's role in modulating age-related health declines.

Main Methods:

Mini-review of existing research on the ACTN3 polymorphism in elderly populations.
Analysis of studies correlating ACTN3 genotype with muscle phenotype, bone mineral density, and metabolic health.

Main Results:

The ACTN3 polymorphism significantly affects muscle characteristics and bone mineral density in the elderly.
Evidence suggests this polymorphism may modulate the risk of metabolic disorders.
Genotype-specific impacts on muscle and bone health are demonstrable.

Conclusions:

ACTN3 genotype knowledge can inform personalized risk management strategies for the elderly.
Insights into ACTN3 may drive tailored exercise program design for healthier aging.
Understanding ACTN3 contributes to maintaining health and function in advanced age.