Related Experiment Video

Updated: Feb 14, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.7K

Ceftaroline for Suspected or Confirmed Invasive Methicillin-Resistant Staphylococcus aureus: A Pharmacokinetic Case

Jeffrey J Cies, Wayne S Moore1, Adela Enache2

  • 1The Center for Pediatric Pharmacotherapy LLC, Pottstown, PA.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|February 9, 2018
PubMed

Insights

Ceftaroline pharmacokinetics in critically ill children differ from adults, showing faster clearance and larger volume of distribution. Higher doses may be needed for effective treatment of methicillin-resistant Staphylococcus aureus infections.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat in pediatric intensive care units (PICUs).
  • Ceftaroline is a key antibiotic for treating MRSA infections, but its pharmacokinetic profile in critically ill children is not well-established.
  • Understanding ceftaroline pharmacokinetics is crucial for optimizing treatment and improving patient outcomes.

Purpose of the Study:

  • To characterize the pharmacokinetics of ceftaroline in critically ill children with suspected or confirmed MRSA infections.
  • To evaluate the microbiological and clinical outcomes of ceftaroline treatment in this population.
  • To inform potential adjustments in dosing strategies for pediatric patients.

Main Methods:

  • Retrospective review of electronic medical records from a pediatric hospital.
  • Analysis of ceftaroline samples for therapeutic drug management in critically ill children.
  • Evaluation of microbiological and clinical response in patients with documented MRSA infections.

Main Results:

  • Seven pediatric patients received ceftaroline for MRSA infections.
  • Pharmacokinetic analysis revealed increased volume of distribution (86%), increased clearance (71%), and shorter half-life (100%) compared to package insert estimates.
  • All six evaluable patients (100%) achieved a positive microbiological and clinical response.

Conclusions:

  • Ceftaroline pharmacokinetics in critically ill children differ significantly from healthy pediatric and adult populations.
  • Faster clearance and larger volume of distribution suggest that current dosing may be insufficient.
  • Higher doses or more frequent dosing intervals of ceftaroline may be necessary to achieve optimal therapeutic exposures in PICU patients.
Abstract

More Related Videos

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

17.7K
Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

12.4K

Related Concept Videos

Confirmation Biases01:31

Confirmation Biases

The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
8.3K
Resistors In Series01:10

Resistors In Series

A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination. 
In a series circuit, the...
6.8K
Series Resonance01:17

Series Resonance

The RLC circuit impedance is defined as the ratio of the supply voltage to the circuit current. Resonance in such a circuit occurs when the imaginary part of this impedance equals zero. This specific condition means that the inductive reactance is exactly equal to the capacitive reactance. The frequency at which this happens is known as the resonant frequency. Mathematically, the resonant frequency is inversely proportional to the square root of the product of the inductance (L) and capacitance...
887
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.1K
Series and Parallel Capacitors01:14

Series and Parallel Capacitors

Capacitors, fundamental components in electronic circuits, can be connected in series and/or parallel configurations. Each configuration has different impacts on the overall behavior of the circuit.
First, consider capacitors connected in series to a battery. In this configuration, the plate connected to the battery's positive terminal develops a positive charge, while the plate attached to the negative terminal becomes negatively charged. An equal magnitude of charge is induced on the...
9.8K